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The Health Epidemic of the 21st Century

Have you seen all the dialysis centers popping up all over the place? If you start looking for them, you will see them everywhere, usually tucked away in a strip mall or a shopping center. I’m sure they are having a banner year and business is only going to get better. Why? Because diabetes is projected to sharply increase another 64% by 2025 and diabetes is the number one cause of chronic kidney failure and people with kidney failure require dialysis.

You may be asking yourself, how does diabetes cause kidney failure? One of the kidney’s main jobs is to filter blood through a complex filtration system of tiny blood vessels but when there is too much sugar in the blood (which is what happens in diabetes), the sugar overload gums up the works and the filtration system stops working. Dialysis is a medical procedure that artificially filters the blood through large hemodialysis units and the procedure usually takes several hours, at least three days per week.

Diabetes Awareness

The intention of this article is to help propagate a message initiated by the researchers who forecasted these statistics on diabetes. They say, “Early detection of prediabetes, in conjunction with lifestyle changes, can reduce the number of people with diabetes. A dramatic reduction in diabetes prevalence over time will require significant lifestyle changes on the part of society as a whole. The purpose of this study is to increase public awareness of the severity of regional diabetes trends by providing detailed forecasts for all states and several metropolitan areas for 2010, 2015, and 2025.”

They have provided us with a crystal ball that reveals our future if something dramatic does not change. But as an individual don’t wait for someone else to do something, the best thing you can do is get educated on what it take to prevent diabetes and start making healthier diet and lifestyle choices today. The question to ask your self is, “would I rather make the effort to eat healthier foods now and spend a few hours per week exercising … or would I rather spend 15 hours per week on dialysis in the future?”

Here are your action items:

  • Understand your genetic risk of diabetes based on your family health history
  • Measure your risk with a Pre-Diabetes blood test
  • Get educated on what it takes to prevent diabetes
  • Start making healthier food choices today
  • Start exercising today

The researchers concluded: “Diabetes is a serious health issue in America, with every indication of a dramatic increase in prevalence, complications, and financial burden on society over the next 15 years. Reversing this “epidemic” will require major lifestyle changes and remaking our health care delivery system into one focused on proactive prevention and continuous access to coordinated, evidence-based management of chronic diseases.”


William R Rowley, Clement Bezold. “Creating public awareness: state 2025 diabetes forecasts.” Population Health Management. Published ahead of print Janury 27, 2012.

American Academy of Anti-Aging Medicine

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Belly Fat Solutions

Okay, so you failed the waist-to-hip ratio measurement that we discussed time, now what? The problem with belly fat is that most of us are genetically programmed to hold onto the calories that we get from our foods. The fact that you are alive today is evidence that your ancestors had the genetic fortitude to survive famines, just about every culture and continent has had them.

So most of us are preprogrammed to have “thrifty genes” which makes us hoard our calories in preparation for the next potential famine. This is a very powerful survival mechanism that the human race is blessed with, but now it’s killing us. The pendulum has swung the other direction and now we have so much abundance of calories (most of them processed) that we are getting fat, sick, diabetic, and as we discussed last time we’re dying from sudden cardiac death. At the root of the belly fat accumulation is insulin resistance.

You are at risk of insulin resistance if you have any three of the following five characteristics:

  • Waist circumference more than 35 inches for a woman and more than 40 inches for a man
  • Fasting serum glucose over 100 mg/dL
  • Triglycerides (blood fats) over 150 mg/dL
  • HDL less than 50 mg/dL for a woman and less than 40 mg/dL for a man
  • Blood pressure over 130/85 or someone requiring blood pressure medication


This syndrome is related to excessive consumption of refined carbohydrates that rapidly metabolize into sugar and is connected to weight gain, elevated cholesterol and triglycerides, hypertension, diabetes, atherosclerosis, polycystic ovary disease, magnesium loss, acidic pH, decreased serum phosphorus, and Candida overgrowth. Eventually the level of insulin is high enough in the bloodstream that it becomes a significant health issue itself. Vitamin, mineral and other nutritional deficiencies are also predisposing factors along with lack of exercise and poor food choices.

An article written in the Journal of the American Medical Association (JAMA) estimates that greater than 25% of Americans (now about 75 million) have insulin resistance. The rate in Latin Americans is even higher. And most likely, another sizable group is hovering just under qualifying levels in one or more of the parameters that define this metabolic disorder. The survey reported in this article was from a few years ago. Has the situation improved since? Twenty percent (20%) of American children are overweight. Twenty-five percent (25%) ages 4-10 and 21% of those ages 11-18 have early signs of Type 2 diabetes demonstrated through impaired glucose intolerance.

At the root of Insulin Resistance Syndrome (IRS) are unhealthy food choices. In our overabundant commodity food crop culture, our exposure to lower quality foods produced from the government subsidized crops like corn, soybeans, rice, and wheat is creating metabolic imbalances in our bodies of epidemic proportions. Because these crops are cheaper for the farmer to sell them than it is to produce them (thanks to the subsidy), manufacturers use these crops to produce “foods” that are calorie-dense and nutrient-poor.

Therefore, the centerpiece to preventing and reversing IRS is healthy food choices. Go to your food pantry and your refrigerator and throw out anything that contains the following ingredients: high-fructose corn syrup, partially hydrogenated soybean oil (or any kind of partially hydrogenated oil), refined flour, or sugar (as the first or second ingredient). If you have nothing left in your pantry to eat, you need a serious dietary paradigm shift. Now replace those “foods” with some real food like 100% whole grains (oats, brown rice, etc.), a variety of vegetables (click here if you need some ideas), lean proteins (eggs, poultry, fish, tofu, etc.), and some fruit, berries, and nuts.

Here are some targeted nutritional supplements that I recommend if you have any 3 out of the 5 characteristics of Insulin Resistance:

1.            NewGreens™: take one scoop 15 minutes before your largest meal, 1-2 times per day. The ingredients in this product will help to curb your appetite and provide nutrients that regulate blood sugar control, increase your resistance to stress, and inhibit free radical damage.

2.            Glucose Support Formula™: take 1 capsule, 2 times per day with the biggest meals. This product has nutrients in it that help to resensitize the cells to allow insulin to open the lock and let glucose flow in. There are also nutrients that help promote healthy glucose and fat metabolism.

3.            Fiber (like Glucomannan): Fiber has been shown to reduce the level of insulin required to process food.

4.            High quality Multivitamin-mineral product (check out the Men’s Pure Pack and Women’s Pure Pack which also include a fish oil and a vitamin D3 supplement):  If you are not already taking a high quality multi vitamin-mineral, this is a very good high-potency multi that will help prevent deficiencies.

5.            Pure Q10™: take 1-2 capsules per day. Studies have shown that 120 mg of coenzyme Q10 reduces glucose and insulin blood levels in people with high blood pressure and heart disease.

Finally, the last recommendation is regular exercise. Studies show that both aerobic exercise and strength training improves insulin sensitivity in healthy and insulin-resistant people. Exercise also has many benefits by reducing the risk factors associated with IRS and preventing some of the associated diseases like cardiovascular disease, diabetes, and even some cancers.

We are now offering an Insulin Resistance Syndrome blood chemistry panel that includes a lipid panel (cholesterol, LDL, HDL, VLDL, LDL/HDL ratio, triglycerides), fasting glucose, C-Reactive Protein (CRP), and homocysteine. Also consider having your cortisol evaluated with an Adrenal Hormone Panel.


Key References:

Pollan  M, “Farmer in Chief” New York Times Magazine, October 9, 2008.

Williams DE, Prevost AT, Whichelow MJ, et al. A cross-sectional study of dietary patterns with glucose intolerance and other features of the metabolic syndrome. Br J Nutr 2000;83:257–66.

Torjesen PA, Birkeland KI, Anderssen SA, et al. Lifestyle changes may reverse development of the insulin resistance syndrome. The Oslo Diet and Exercise Study: a randomized trial. Diabetes Care 1997;20:26–31.

Barnard RJ, Wen SJ. Exercise and diet in the prevention and control of the metabolic syndrome. Sports Med 1994;18:218–28 [review].

Singh RB, Niaz MA, Rastogi SS, et al. Effect of hydrosoluble coenzyme Q10 on blood pressures and insulin resistance in hypertensive patients with coronary artery disease. J Hum Hypertens 1999;13:203–8.

van Baak MA, Borghouts LB. Relationships with physical activity. Nutr Rev 2000;58:S16–S18 [review].

Borghouts LB, Keizer HA. Exercise and insulin sensitivity: a review. Int J Sports Med 2000;21:1–12 [review].

Lempiainen P, Mykkanen L, Pyorala K, et al. Insulin resistance syndrome predicts coronary heart disease events in elderly nondiabetic men. Circulation 1999;100:123–8.

Vanhala MJ, Pitkajarvi TK, Kumpusalo EA, Takala JK. Obesity type and clustering of insulin resistance-associated cardiovascular risk factors in middle-aged men and women. Int J Obes Relat Metab Disord 1998;22:369–74.

Yip J, Facchini FS, Reaven GM. Resistance to insulin-mediated glucose disposal as a predictor of cardiovascular disease. J Clin Endocrinol Metab 1998;83:2773–6.

Pyorala M, Miettinen H, Halonen P, et al. Insulin resistance syndrome predicts the risk of coronary heart disease and stroke in healthy middle-aged men: the 22-year follow-up results of the Helsinki Policemen Study. Arterioscler Thromb Vasc Biol 2000;20:538–44.

Moore MA, Park CB, Tsuda H. Implications of the hyperinsulinaemia-diabetes-cancer link for preventive efforts. Eur J Cancer Prev 1998;7:89–107 [review].

Stoll BA. Western nutrition and the insulin resistance syndrome: a link to breast cancer. Eur J Clin Nutr 1999;53:83–7 [review].

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Belly Fat and Sudden Cardiac Death

If the shape of your upper body looks like an apple, you may be at a higher risk for sudden cardiac death. A recent study investigated a whole bunch of various cardiovascular risk factor markers and found that a measurement of waist-to-hip ratio had the greatest predictive value for sudden cardiac risk. Obesity has been associated with a higher risk of sudden cardiac death in two other well-known large-population studies: Framingham Heart Study and the Nurses’ Health Study.

This recent analysis by Selcuk Adabag, MD and colleagues, took it a step further by examining three different measures of obesity – BMI, waist circumference, and waist-to-hip ratio. And then after further adjustment for obesity-related comorbidities that could be involved in sudden cardiac death – including diabetes, LDL cholesterol, hypertension, prevalent coronary heart disease, heart failure, and left ventricular hypertrophy – waist-to-hip ratio was the only one left as a significant predictor of sudden cardiac death.

Obesity “is a root cause of problems,” said Dr. Adabag in an interview. “People, particularly physicians, need to be paying attention to weight gain and should actively work on reducing weight.”

Measure Your Risk Factor

The World Health Organization (WHO) has a specific protocol for this measurement. In a lean person (see picture), the waist can be measured at its narrowest point, while for a person with convex waist (see picture), it may be measured at about one inch above the navel. The hip is measured at its widest portion of the buttocks or hips.

Source: Wikipedia

World Health Organization

The WHO states that abdominal obesity is defined as a waist-to-hip ratio above 0.90 for males and above 0.85 for females. Get your measurements and check back for our follow up about what to do if your ratio is elevated.


Adabag S, et al “Risk of sudden cardiac death in obese individuals: The Atherosclerosis Risk in Communities (ARIC) study” HRS 2012.

American Academy of Anti-Aging Medicine

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The Cardiovascular Benefits of NewGreens


Cardiovascular disease (CVD) represents one of the most prevalent causes of morbidity and mortality in the U.S. population today. CVD is expected to be the leading cause of death in the western world in the next 15 years secondary to the increasing prevalence of diabetes and obesity.1 Currently, CVD accounts for approximately 38 percent of all deaths in North America. Our understanding of the processes which contribute to the development of CVD has improved significantly. As a result, much of the research in this field has focused on four aspects of this disease process: prevention of endothelial cell (blood vessel wall) dysfunction and inflammation, medical and dietary treatment of abnormal lipid profiles, treatment and control of hypertension, and the recognition and treatment of hypercoagulable (increased blood clotting) disorders. In the study of these areas, many active compounds, or phytonutrients, found in everyday foods have been shown to have significant effects toward the modulation of CVD. This review is intended to serve as a summary of the current evidence regarding the effect of certain classes of phytonutrients on the development of CVD.

Essentia Blend®

Key active ingredients: Alfalfa, Barley grass, Chlorella, Spirulina

Diets rich in whole grains have been reported to result in lower rates of CVD.2 Several studies have shown that these compounds possess properties associated with improved lipid profiles, reduced blood pressure, and improved blood vessel dysfunction. The treatment of cholesterol-fed rabbits with 1-4% alfalfa extracts in their diet resulted in a significant reduction in blood cholesterol levels relative to cholesterol-fed rabbits without alfalfa supplementation.3 Behall et al. from Maryland showed that total cholesterol was lowered in human subjects with mild hypercholesterolemia (200-240mg/dL) treated with 3-6g Beta-glucan per day from barley grass over a 5 week period. This barley grass extract also significantly lowered LDL levels in these same subjects.4

A study by Merchant et al. from Virginia showed that dietary supplementation with Chlorella in human subjects with mild to moderate high blood pressure after 5 weeks resulted in the stabilization or reduction of their sitting diastolic blood pressure.5 A basic science study from Japan has shown that sodium spirulan, a component of dietary spirulina, has the ability to stimulate vascular endothelial cells (cells which line blood vessels) to release certain proteoglycans responsible for maintaining the fluid flow of blood and inhibiting coagulation.6

Power Veggie Blend®

Key active ingredients: Carrot, Spinach, Broccoli, Tomato, Beet

Vegetables and vegetable extracts in the diet have long been thought to possess potent effects toward the prevention of CVD. These products contain carotenoids and lycopene with potent antioxidant properties which has resulted in several research studies regarding their specific effect in the cardiovascular system. Bub et al. from the Netherlands studied the effects of 6-8 weeks of carrot, spinach, and tomato supplementation on the lipoprotein carotenoid concentration and LDL oxidation in 23 healthy men. They concluded that overall carotenoid supplementation resulted in higher lipoprotein carotenoid concentrations while tomato juice resulted in a significant reduction in plasma LDL oxidation.7

A study by the department of neurosurgery from the University of South Florida studied the anti-oxidant effects of spinach, blueberry, and spirulina on damage to the brain after stroke. They determined that 4 weeks of supplementation resulted in a significant decrease in ischemia (stroke)-induced brain cell death.8

In a large, multi-center, case-control study covering ten European countries examining the correlation of anti-oxidant status and acute myocardial infarction (heart attack), elevated levels of lycopene from tomatoes was found to be protective.9

A group from Canada studied the effects of 14 weeks of 200mg/day broccoli supplementation on the cardiovascular status of hypercholesterolemic, stroke-prone rats. This group found that broccoli supplementation resulted in a decrease in both inflammation and oxidative stress in cardiovascular tissues, as well as average blood pressure as compared to controls.10 A group from North Carolina has reported that red wine contains high levels of betaine, an extract from beet sugar, that has been hypothesized to contribute to the anti-oxidant and cardioprotective effects of the red wine itself.11

Antioxidant Supreme Blend®

Key active ingredients: Apple, Cherry, Cranberry, Grapeseed, Green tea extract, Quercetin

The anti-oxidant properties of plant extracts such as phenolic, flavonoids, and carotenoids have been shown to possess the ability to attenuate the causes and sequelae of CVD. The Women’s Health Study studied the effects of flavonoids on CVD and included approximately 40,000 subjects with a 6.9 year follow-up. They concluded that the women ingesting the highest levels of flavonoids had a 35% reduction in the risk of cardiovascular events (stroke, heart attack) and those ingesting apples had a 13-22% reduction in CVD risk factors.12 Furthermore, Aprikian et al. found that when cholesterol fed rats were supplemented with lyophilized apples, there was a significant drop in plasma cholesterol and liver cholesterols with an increase in HDL.13

A group from France studied the effects of sour cherry seed extracts on the effects of retinal ischemia, a common sequela of stroke. They reported that the two week supplementation of sour cherry seeds in the diet of rats resulted in a decrease in certain inflammatory proteins after retinal ischemia compared to controls.14

The effects of cranberries and their extracts on plasma lipid profiles were studied in 21 men who were given 7ml/kg of cranberry juice for a 14-day period. This short-term dietary change was associated with a significant increase in plasma antioxidant capacity and reduction in circulating oxidized-LDL concentrations.15 The effect of a single, high-level, non-toxic dose of the grapeseed extract, procyanidin, on the lipid profiles of rats was studied. This group from Spain determined that this single dose delivery resulted in a significant decrease in levels of plasma triglycerides, free fatty acids, apolipoprotein B(apoB), and LDL-cholesterol with a slight increase in HDL-cholesterol.16

Green tea extract and, more specifically, its most active compound epigallocatechin-3-gallate (EGCG) have been shown in both animal and human studies to effect the development and incidence of CVD. Sano et al. from Japan conducted a human trial of 203 subjects to examine the relationship of green tea intake with CVD. They determined that the incidence of coronary artery disease decreased as the amount of green tea consumed per day increased.17 When EGCG was administered to rats after inducing a heart attack, this treatment resulted in a significant decrease in specific inflammatory pathways including NF-KB and AP-1.18

A trial of the flavonoid quercetin was done in human subjects by administering either 150 of 300mg daily. This study showed that quercetin is bioavailable in oral form and succeeds in significantly decreasing platelet aggregation, a key component of blood clot formation.19

Gentle Fiber Blend®

Key active ingredients: Flaxseed meal, Guar Gum, Glucomannan

In recent studies, dietary fiber and their corresponding phytoestrogens have been suggested to play a role in the treatment of hypercholesterolemia. In a double-blinded, randomized study of the effects of flaxseed supplementation on the lipid profiles of 58 post-menopausal women conducted at the University of Oklahoma, researchers found that 40g daily of flaxseed over 3 months resulted in a reduction of total cholesterol and non-HDL-cholesterol by 6% with relative reductions in triglyceride levels of 12.8%.20

When glucomannan was given to cholesterol-fed rats, those treated with the glucomannan supplement showed significantly lower cholesterol levels, higher HDL levels, and lower lipid peroxidation levels relative to those not treated with glucomannan.21

In a rat model, researchers from France have shown that the addition of guar gum to a regular diet resulted in a decrease in total cholesterol as a result of altered intestinal bile acid reabsorption.22

Restorative Detox Blend®

Key active ingredients: Resveratrol, Ginkgo biloba, Curcumin, Bilberry, Ginger

Many of the known polyphenols, ginkgolides, curcuminoids, and anthocyanins have been found to promote vascular health in a multitude of ways. Resveratrol, a polyphenolic compound found in red wine, was found to upregulate the nitric oxide pathway in rats, potentially providing a cardio-protective effect while also preserving endothelium-dependent relaxation in arterial samples from humans undergoing coronary-artery bypass grafting.23, 24

Treatment of human aortic endothelial cells with ginkgo biloba extract at 50µg/ml for 18 hours resulted in a decrease in TNF-alpha induced inflammation and endothelial adhesiveness as measured by intracellular reactive oxygen species formation, NF-kappaB and AP-1 activation, and adhesion molecule expression.25

Homocysteinemia, high levels of a protein present in human serum as a common part of biochemical pathways, has been shown in many studies to create a increased tendency for blood to coagulate. As a result, physicians now recognize homocysteinemia as an independent risk factor for the development of CVD similar to diet, smoking, and activity levels. Ramaswami et al. from the Baylor School of Medicine has shown that the homocysteine-induced superoxide-anion production and eNOS downregulation, which contributes to endothelial dysfunction and impaired healing in the vessel wall, is significantly blocked by curcumin treatment.26 They suggested that dietary curcumin, along with proper vitamin supplementation, play a key role in the treatment of patients with hyperhomocysteinemia.

The treatment of porcine coronary arteries with the anthocyanin extract bilberry has been shown to preserve endothelium-dependent relaxation while protecting the arteries from reactive-oxygen species.27

A group from Australia showed that gingerols, the active compound in ginger, are effective in inhibiting platelet activation in similar fashion to aspirin. They noted that the effect of gingerols was approximately half of that of aspirin and likely functioned similarly by inhibiting COX enzyme activity.28


With cardiovascular disease increasing in prevalence and projected to become the leading cause of death of all humans, myriad prevention and treatment avenues have been studied. Growing evidence suggests that in addition to lifestyle modifications, smoking cessation, and medical therapy, dietary compounds and supplements may play a significant role in the treatment of this disease process.

In modern day society, however, including these compounds in their recommended doses from food is becoming increasingly difficult. These dietary supplements may have a role in altering lipid profiles, improving hypertension, treating hypercoagulable states, and reducing the inflammation that leads to atherogenesis amongst other effects.

As more research is done in this continuously expanding field of knowledge, natural compounds will continue to provide new insights and novel therapies in our fight against CVD.

Written with exclusive rights for Pure Prescriptions, Inc.


1. Murray CJ, Lopez AD. Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study. Lancet ;349:1436-42, 1997.

2. Rimm EB, Ascherio A, Giovannucci E, Spiegelman D, Stampfer MJ, Willett WC. Vegetable, fruit and cereal fiber intake and risk of coronary heart disease among men. JAMA ;275:447­51, 1996.

3. Malinow, MR et al. Alfalfa saponins and alfalfa seeds. Dietary effects in cholesterol-fed rabbits. Atherosclerosis; 37(3): 433-8, 1980.

4. Behall et al. Diets containing barley significantly reduce lipids in mildly hypercholesterolemic men and women. Am J Clin Nutr.; 80: 1185­93, 2004.

5. Merchant RE, Andre CA, Sica DA. Nutritional supplementation with Chlorella pyrenoidosa for mild to moderate hypertension. J Med Food.; 5(3): 141-52, 2002

6. Yakamoto, C. et al. Proteoglycans Released from Cultured Bovine Aortic Endothelial Cell Layers by Sodium Spirulan Are Both Perlecan and Biglycan. Biol. Pharm. Bull.; 28(1): 32-36, 2005.

7. Bub et al. Moderate Intervention with Carotenoid-Rich Vegetable Products Reduces Lipid Peroxidation in Men. J. Nutr.; 130: 2200­2206, 2000.

8. Wang et al. Dietary supplementation with blueberries, spinach, or spirulina reduces ischemic brain damage. Experimental Neurology; 193: 75­ 84, 2005.

9. Rao AV. Lycopene, tomatoes, and the prevention of coronary heart disease. Exp Biol Med; 227(10): 908­ 13, 2002.

10. Wu et al. Dietary approach to attenuate oxidative stress, hypertension, and inflammation in the cardiovascular system. PNAS; 101(18): 7094­7099, 2004. 11. Mar, M-H et al. Betaine in wine: answer to the French paradox? Medical Hypotheses; 53(5): 383­385, 1999.

12. Sesso H, Gaziano JM, Liu S, Buring J: Flavonoid intake and risk of cardiovascular disease in women. Am J Clin Nutr.; 77: 1400-1408, 2003.

13. Aprikian O, Levrat-Verny M, Besson C, Busserolles J, Remesy C, Demigne C: Apple favourably affects parameters of cholesterol metabolism and of anti-oxidative protection in cholesterol fed rats. Food Chem.; 75: 445-452, 2001.

14. Szabo, M. et al. Heme Oxygenase-1­Related Carbon Monoxide and Flavonoids in Ischemic/Reperfused Rat Retina. Invest Ophthalmol Vis Sci.; 45: 3727­3732, 2004.

15. Ruel, G. et al. Changes in plasma antioxidant capacity and oxidized low-density lipoprotein levels in men after short-term cranberry juice consumption. Metabolism; 54(7): 856-61, 2005.

16. Del Bas, J.M. et al. Grape seed procyanidins improve atherosclerotic risk index and induce liver CYP7A1 and SHP expression in healthy rats. FASEB; 10.1096/fj.04-3095fje, 2005.

17. Sano, J. et al. Effects of Green Tea Intake on the Development of Coronary Artery Disease. Circ J.; 68: 665 ­670, 2004.

18. Aneja, R. et al. Epigallocatechin, a Green Tea Polyphenol, Attenuates Myocardial Ischemia Reperfusion Injury in Rats. Molecular Medicine; 10(1-6): 55-62, 2004.

19. Hubbard GP, Wolffram S, Lovegrove JA, Gibbins JM. Ingestion of quercetin inhibits platelet aggregation and essential components of the collagen-stimulated platelet activation pathway in humans. J Thromb Haemost.; 2: 2138­45, 2004. 20. Lucas, E.A. et al. Flaxseed Improves Lipid Profile without Altering Biomarkers of Bone Metabolism in Postmenopausal Women. J Clin Endocrinol Metab; 87: 1527­1532, 2002.

21. Yoshida, M. et al. Effects of long-term high-fiber diet on macrovascular changes and lipid and glucose levels in STZ-induced diabetic SD rats. Diabetes Res Clin Pract.; 13(3): 147-52, 1991.

22. Moriceau, S. et al. Cholesterol-lowering effects of guar gum: changes in bile acid pools and intestinal reabsorption. Lipids; 35(4): 437-44, 2000.

23. Das, S. et al. Coordinated induction of iNOS­VEGF­KDR­eNOS after resveratrol consumption: A potential mechanism for resveratrol preconditioning of the heart. Vascular Pharmacology; 42: 281 ­ 289, 2005.

24. Rakici, O. et al. Effects of resveratrol on vascular tone and endothelial function of human saphenous vein and internal mammary artery. International Journal of Cardiology; 105: 209­ 215, 2005.

25. Chen, J-W. et al. Ginkgo biloba Extract Inhibits Tumor Necrosis Factor alpha­Induced Reactive Oxygen Species Generation, Transcription Factor Activation, and Cell Adhesion Molecule Expression in Human Aortic Endothelial Cells. Arterioscler Thromb Vasc Biol.; 23: 1559-1566, 2003.

26. Ramaswami et al. Curcumin blocks homocysteine-induced endothelial dysfunction in porcine coronary arteries. J Vasc Surg; 40:1216-22, 2004.

27. Bell, D.R. et al. Direct Vasoactive and Vasoprotective Properties of Anthocyanin Rich Extracts. J Appl Physiol.; doi:10.1152/japplphysiol.00626.2005.

28. Koo, K.L.K. et al. Gingerols and Related Analogues Inhibit Arachidonic Acid-Induced Human Platelet Serotonin Release and Aggregation. Thrombosis Research; 103: 387­397, 2001.

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Fish Oil the Way Nature Intended

Hopefully you know about omega-3 fatty acids by now, but are you getting it the way nature intended? The natural triglyceride form is the type of omega- 3 found in the foods we eat. Here is a quick reminder of the necessity of omega-3 fatty acids:


Every Cell in the Body Uses essential fatty acids (EFAs):


  • The body is made out of cells
  • Cells are made out of membranes
  • Membranes are made out of fats
  • Good fats build good membranes


Choose it for Cardiovascular Health …

Omega-3 fish oil promotes the elasticity of coronary arteries. Without omega-3, artery walls can become rigid with microscopic fractures that can become receptacles for bad cholesterol and life-threatening.


Cardiovascular Health Benefits

  • Reduces platelet aggregation (stickiness)
  • Improves endothelial function
  • Improves blood and oxygen supply to heart
  • Lowers triglyceride levels
  • Lowers blood pressure by vasodilation and promotion of sodium excretion


Choose it for Joint Mobility …

Omega-3 fish oil fights joint disease by maintaining cell and joint flexibility. Omega-3 fatty acids also provide building blocks for your body’s anti-inflammatory system which decreases pain and tenderness as well as decreases the need for anti-inflammatory drugs.


Choose it for Brain Health …

Omega-3 fish oil increases brain function and supports neurotransmission in the brain, increasing memory and intellectual capacity.


DHA for The Brain

  • 60% of the brain’s dry weight is fat
  • 25% of this fat is DHA
  • The synaptic membrane has a higher concentration of DHA than almost any tissue in the body
  • Studies of patients suffering from schizophrenia and ADHD show that increasing levels of DHA has beneficial impact on brain function


Choose it for Anti-Aging …

Omega-3 fish oil fights signs of aging by maintaining and replenishing the optimum cellular moisture balance in the skin. Without omega-3, skin cells age prematurely.


The science

Recent research demonstrated that the bioavailability of the natural triglyceride type fish oil was double that of the ethyl esters. Blood concentrations of EPA and DHA were 52 to 60 percent higher after taking natural triglyceride fish oil than after taking ethyl ester fish oil.


The natural form of omega-3 EPA and DHA is significantly more bioavailable for absorption through cellular membranes found in fish oil than from flaxseed oil or borage oil. In fact, vegetable oils like flax and borage do not contain any naturally occurring EPA or DHA at all. Instead, they contain the fatty acid alpha-linolenic, which converts to EPA and DHA when ingested. The conversion, however, is poor at only 4-6%, and is dependent on an individual’s diet and state of wellness.


A product from Pure Prescriptions called Ultimate Omega-3 has one of the highest percentages of natural omega-3 fatty acids available without a prescription. Ultimate Omega-3 features VESIsorb® (a patented delivery system), providing a 567% increase in absorption and greater bioavailability compared to regular fish oil capsules. One Ultimate Omega-3 softgel delivers a dose of EPA/DHA equivalent to six regular fish oil capsules.


Be sure to make the right choice when choosing your fish oil.



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  • Peet, et al. Two double–blind placebo–controlled pilot studies of eicosapentaenoic acid in the treatment of schizophrenia. Schizophr Res. 2001; 49(3):243–251.
  • Peet, Horrobin, et al. A dose–ranging study of the effects of ethyl–eicosapentaenoate in patients with ongoing depression despite apparently adequate treatment with standard drugs. Archives of General Psychiatry. 2002; 59:913–919.
  • James, et al. Dietary n–3 fatty acids and therapy for rheumatoid arthritis. Semin Arthritis Rheum. 1997; 27:85–97.
  • Puri, et al. The use of eicosapentaenoic acid in the treatment of chronic fatigue syndrome. Prostaglandins, Leukotrienes and Essential Fatty Acids. 2004; 70:399–401.
  • Theodoratou, et al. Dietary fatty acids and colorectal cancer: a case–control study. American Journal of Epidemiology. 2007; 166(2):181–195.
  • Terry, et al. Increased fatty fish consumption may reduce prostate cancer risk. Lancet. 2001; 357(9269):1764–1766.
  • Volker, et al. Efficacy of fish oil concentrate in the treatment of rheumatoid arthritis. J Rheumatol. 2000; 27:2343–2346.
  • Cleland, et al. The role of fish oils in the treatment of rheumatoid arthritis. Drugs. 2003; 63:845–853.
  • Frangou, et al. Efficacy of ethyl–eicosapentaenoic acid in bipolar depression: randomised double–blind placebo–controlled study. British Journal of Psychiatry. 2006; 188:46–50.
  • Zanarini, et al. Omegan–3 Fatty Acid Treatment of Women With Borderline Personality Disorder: A Double–Blind, Placebon–Controlled Pilot Study. Journal of Clinical Psychiatry. 2003;  160:167n–16.
  • Genuis, et al. Time for an oil check: the role of essential omegan–3 fatty acids in maternal and pediatric health. Journal of Perinatology. 2006; 26(6):359n–65.
  • Gelder, et al. Fish consumption, n–3 fatty acids, and subsequent 5n–y cognitive decline in elderly men: the Zutphen Elderly Study. American Journal of Clinical Nutrition. 2007; 85:1142n–7.
  • Hibbeln, et al. Annual Meeting of the American Psychiatric Association; San Francisco. 2003.
  • Denburg, et al. Fish oil supplementation in pregnancy modifies neonatal progenitors at birth in infants at risk of atopy. Pediatric Research. 2005; 57(2):276–81.
  • Silvers, et al. Randomised double–blind placebo–controlled trial of fish oil in the treatment of depression. Prostaglandins Leukot Essent Fatty Acids. 2005; 72(3):211–8.
  • Zampelas, et al. Fish Consumption Among Healthy Adults Is Associated With Decreased Levels of Inflammatory Markers Related to Cardiovascular Disease. Journal of the American College of Cardiology. 2005; 46:120n–124. (ATTICA).
  • Sinn, et al. Effect of supplementation with polyunsaturated fatty acids and micronutrients on learning and behavior problems associated with child ADHD. Journal of Developmental & Behavioral Pediatrics. 2007; 28(2):82–91.
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The Next Level of CoQ10

The Next Level of CoQ10


CoQ10 is also called ubiquinone, a name that signifies its ubiquitous (widespread) distribution in the human body.  CoQ10 is used by the body to transform food into adenosine triphosphate (ATP), the energy on which the body runs.  CoQ10 is a powerful antioxidant that protects the body from free radicals and helps preserve vitamin E, the major antioxidant of cell membranes and blood cholesterol.


Virtually every cell of the human body contains CoQ10.  It is concentrated in the mitochondria, the area of cells where energy is produced.  Most human cells contain hundreds to thousands of mitochondria; the heart contains the most with 5000 mitochondria for each heart cell! Supplementation with CoQ10 has helped some people with congestive heart failure.  Similar improvements have been reported in people with cardiomyopathies – a group of diseases affecting heart muscle.


Also, due to its effect on heart muscle, researchers have studied CoQ10 in people with heart arrhythmias (heart rhythm disturbances, such as atrial fibrillation).  Research in this area reported improvement after approximately one month in people with premature ventricular beats (a form of arrhythmia) who also suffer from diabetes.  Additionally, angina patients taking 150 mg per day of CoQ10 reported a greater ability to exercise without experiencing chest pain.  This has been confirmed in independent investigations.  CoQ10 appears to increase the heart’s tolerance to a lack of oxygen.  Perhaps as a result, preliminary research has shown that problems resulting from heart surgery occurred less frequently in people given CoQ10 compared with the control group.


As an antioxidant, CoQ10 can protect proteins, LDL-cholesterol (bad cholesterol), and mitochondrial DNA from oxidative damage.  Because of its function in the production of cellular energy, and as an antioxidant, CoQ10 can aid in the body’s response to a host of health problems including heart disease, cancer, aging, neuro-degenerative diseases, and muscular dystrophy.


Like many nutrients on the market, not all CoQ10 products are created equally.  Until recently, the most bioavailable form of CoQ10 on the market was suspended in oil and “crystal free.”  But now there is an impressive patented technology called VESIsorb® which is a unique delivery system that makes CoQ10 600% more absorbable than the “regular CoQ10” on the market.  The patented VESIsorb® delivery system is a natural self-assembling colloid delivery system that has been clinically proven to increase absorption of CoQ10.  Pure Q10™ features this technology, which borrows a concept from our own natural biochemistry, making it second to none in the industry.


Key Benefits:


  • Higher dosages of CoQ10 can be formulated in the VESIsorb® delivery system with smaller capsule size compared to other purported bio-enhanced CoQ10 delivery systems.
  • Small softgel for easy swallowing
  • Made in the U.S.A under strict quality control standards (cGMP)
  • Perfect for all adults over 30, all athletes and especially those taking cholesterol lowering (statin) drugs.


CoQ10 is notoriously difficult for the body to absorb as an oral supplement. There have been advancements in absorption technology over the years but nothing has come close to the results of VESIsorb®. Pure Q10™ with VESIsorb® technology makes the CoQ10 ‘pre-digested’ allowing the body to much more easily absorb this all-important nutrient. Based on its greater absorption rates, Pure Q10™ delivers more CoQ10 to the body in less time than other forms, offering greater value per bottle. Theoretically it takes 7-10 regular formulated softgels to reach the same blood levels as just one Pure Q10™ softgel.


Also check out our latest product in the Pure Q10 family of products, Pure Q10 Ubiquinol QH. Check out these highlights:


This next level CoQ10 product comes straight from one of the most well-known and respected CoQ10 manufacturers in the world, Kaneka.


  • KanekaQ10™ is the only yeast-fermented CoQ10 and thus does not contain the impurities that synthetically processed CoQ10 does
  • KanekaQ10™ has been used in the vast majority of all clinical trials over the past 30 years
  • KanekaQ10™ is the CoQ10 with Self-Affirmed GRAS status (“generally recognized as safe”) for use in foods and beverages
  • KanekaQ10™ is the only CoQ10 made in the U.S. and is manufactured per the good manufacturing practices designated by the FDA
  • KanekaQ10™ is Genetically Modified Organism-free, allergen-free and Kosher certified


KanekaQ10™ is proudly featured in Pure Q10 Ubiquinol QH.


Clinical Science

Depleted CoQ10 has been associated with a range of heart conditions (including arrhythmias, strokes, hypertension, heart attacks, and atherosclerosis), and CoQ10 can help prevent and treat these conditions. It also is associated with helping to prevent oxidation of LDL cholesterol. Because of its central role in cell development, it is an energy and brain booster, and can assist in weight loss due to its ability to help speed up metabolism of fats. It has also been successful in fighting periodontal diseases like gingivitis, and in some studies has demonstrated effectiveness as a supplement in treatment of certain cancers, including breast cancer.




  • Z. Xian-Liu et al. Relative Bioavailability Comparison of Different Coenzyme Q10 Formulations with a Novel Delivery System (CoQsource®). Alternative Therapies in Health & Medicine 15(2) 2009, 42-46.
  • Bhagavan HN, Chopra RK. Coenzyme Q10: Absorption, tissue uptake, metabolism and pharmacokinetic. Free Radical Research 2006; 40(5):445-453.
  • Bhagavan HN, Chopra RK. Plasma coenzyme Q10 response to oral ingestion of coenzyme Q10 formulations. Mitochondrion 2007; 7S:S78-S88.
  • Chopra RK, Goldman R, Sinatra ST, Bhagavan HN. Relative Bioavailability of Coenzyme Q10 formulations in Human Subjects. Int J Vit Nutr Res 1998; 68: 109-113.
  • Miles MV, Horn P, Miles L, Tang P, Steele P, DeGrauw T. Bioequivalence of coenzyme Q10 from over-the-counter supplements. Nutr Res 2002; 22:919-929.
  • Molyneux S, Florkowski C, Lever M, George P. The bioavailability of coenzyme Q10 supplements available in New Zealand differs markedly. N Z Med J 2004; 117(1203):U1108
  • Ullmann U, Metzner J, Schulz C, Perkins J, Leuenberger B. A New Coenzyme Q10 Tablet- Grade Formulation (all-Q®) Is Bioequivalent to Q-Gel® and Both Have Better Bioavailability Properties than Q-SorB®. J Med Food 2005; 8(3):397-399.
  • Schulz C, Obermüller-Jevic UC, Hasselwander O, Bernhardt J, Biesalski HK. Comparison of the relative bioavailability of different coenzyme Q10 formulations with a novel solubilizate (SoluTM Q10). Int J Food Sci Nutr 2006; 57(7/8): 546-555.
  • Nukui K, Yamagishi T, Miyawaki H, Kettawan A, Okamoto T, Sato K. Comparison of Uptake between PureSorb-QTM40 and Regular Hydrophobic Coenzyme Q10 in Rats and Humans after Single Oral Intake. J Nutr Sci Vitaminol 2007; 53:187-190.
  • Wajda R, Zirkel J, Schaffer T. Increase of Bioavailability of Coenzyme Q10 and Vitamin E. J Med Food 2007; 10(4):731-734
  • Zmitek J, Smidovnik A, Fir M, Prosek M, Zmitek K, Walczak J, Pravst I. Relative Bioavailability of Two Forms of a Novel Water-Soluble Coenzyme Q10. Ann Nutr Metab 2008; 52:281-287.
  • Zita C, Overvad K, Mortensen SA, Sindberg CD, Moesgaard S, Hunter DA. Serum coenzyme Q10 concentrations in healthy men supplemented with 30 mg or 100 mg coenzyme Q10 for two months in a randomized controlled study. BioFactors 2003; 18:185-193.
  • Singh RB, Niaz MA, Kumar A, Sindberg CD, Moesgaard S, Littarru. Effect on absorption and oxidative stress of different oral Coenzyme Q10 dosages and intake strategy in healthy men. BioFactors 2005; 25:21-9-224.
  • Shults CW, Beal MF, Song D, Fontaine D. Pilot trial of high dosages of coenzyme Q10 in patients with Parkinson’s disease. Experimental Neurology 2004; 188:491- 494.
  • Kaikkonen J, Nyyssönen K, Porkkala-Sarataho E, Poulsen HE, Metsä-Ketelä T, Hayn M, Salonen R, Salonen JT. Effect of oral coenzyme Q10 supplementation on the oxidation resistance of human VLDL + LDL fraction: Absorption and antioxidative properties of oil and granule-based preparations. Free Radical Biology & Medicine 1997; 22(7):1195-1202.
  • Shults, C.W., Oakes, D., Kieburtz, K., Beal, M.F., Haas, R., Plumb, S., Juncos, J.L., Nutt, J., Shoulson, I., Carter, J., Kompoliti, K., Perlmutter, J.S., Reich, S., Stern, M., Watts, R.L., Kurlan, R., Molho, E., Harrison, M., Lew, M. Effect of Coenzyme Q10 in early Parkinson disease. Arch. Neurol. 2002; 59: 1541-1550.
  • Langsjoen PH, Langsjoen AM. Supplemental Ubiquinol in patients with advanced congestive heart failure. Accepted for publication and in print in BioFactors 2008.
  • Williams, K.D., Maneke, J.D., AbdelHameed, M., Hall, R.L., Palmer, T.E., Kitano, M., Hidaka, T. 52-week oral gavage chronic toxicity study with ubiquinone in rats with a 4-week recovery. J. Agric. Food Chem. 1999; 47: 3756-3763.
  • The Huntington Study Group. A randomized, placebo-controlled trial of coenzyme Q10 and remacemide in Huntington’s disease. Neurology 2001; 57: 397-404.
  • Baggio, E., Gandini, R., Plancher, A.C., Passeri, M., Carmosino, G. Italian multicenter study on the safety and efficacy of coenzyme Q10 as adjunctive therapy in heart failure. Mol. Aspects Med. 1994; 15: s287-s294.
  • Ikematsua H., Nakamura K., Harashima S., Fujii K, Fukutomi N. Safety assessment of coenzyme Q10 (Kaneka Q10) in healthy subjects: A double-blind, randomized, placebo- controlled trial. Regulatory Toxicology and Pharmacology 2006; 44:212-218.
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Being Smart in the Sun

I burnt my son last weekend. Okay, I didn’t actually burn him but I failed to properly protecting him from the sun and he got a stinging sunburn on his face and neck. I felt bad enough to write an article about it. Coincidentally, this is also Skin Cancer Detection and Prevention Month so the time was right.

The sunscreen debate

The issue with sunscreen is that there are some good ones and there are some other ones that are so bad they are actually harmful. I closely follow the research from the Environmental Working Group (EWG) and they recently published some simple and useful information that you can start using today to protect yourself and your loved ones from the harmful effects of the sun and the harmful effects of some sunscreens that are loaded with toxic chemicals.

Here are some great tips from EWG:

1. Quick tips for a good sunscreen

Ingredients matter – learn if your brand leaves you overexposed to damaging UVA rays, if it breaks down in the sun or if it contains potential hormone-disrupting compounds.

2. First things first – do these before applying sunscreen

The best defenses against getting too much harmful UV radiation are protective clothes, shade and timing. Check out the checklist:

Don’t get burned. Red, sore, blistered (then peeling) skin is a clear sign you’ve gotten far too much sun. Sunburn increases skin cancer risk – keep your guard up!

Wear clothes. Shirts, hats, shorts and pants shield your skin from the sun’s UV rays – and don’t coat your skin with goop. A long-sleeved surf shirt is a good start.

Find shade – or make it. Picnic under a tree, read beneath an umbrella, take a canopy to the beach. Keep infants in the shade – they lack tanning pigments (melanin) to protect their skin.

Plan around the sun. If your schedule is flexible, go outdoors in early morning or late afternoon when the sun is lower in the sky. UV radiation peaks at midday, when the sun is directly overhead.

Sunglasses are essential. Not just a fashion accessory, sunglasses protect your eyes from UV radiation, a cause of cataracts.

3. Now put on sunscreen – here are the essentials

Some sunscreens prevent sunburn but not other types of skin damage. Make sure yours provides broad spectrum protection and follow our other tips for better protection.

Don’t be fooled by a label that boasts of high SPF. Anything higher than “SPF 50+” can tempt you to stay in the sun too long, suppressing sunburn but not other kinds of skin damage. The FDA says these numbers are misleading. Stick to SPF 15-50+, reapply often and pick a product based on your own skin coloration, time planned outside, shade and cloud cover.

News about Vitamin A. Eating vitamin A-laden vegetables is good for you, but spreading vitamin A on the skin may not be. Government data show that tumors and lesions develop sooner on skin coated with vitamin A-laced creams. Vitamin A, listed as “retinyl palmitate” on ingredient labels, is in one-fourth of sunscreens on the market. Avoid them.

Ingredients matter. Avoid the sunscreen chemical oxybenzone, a synthetic estrogen that penetrates the skin and contaminates the body. Look for active ingredients zinc, titanium, avobenzone or Mexoryl SX. These substances protect skin from harmful UVA radiation and remain on the skin, with little if any penetrating into the body. Also, skip sunscreens with insect repellent – if you need bug spray, buy it separately and apply it first.

Pick a good sunscreen. EWG’s sunscreen database rates the safety and efficacy of about 1,800 SPF-rated products, including about 800 sunscreens for beach and sports. We give high ratings to brands that provide broad spectrum, long-lasting protection with ingredients that pose fewer health concerns when absorbed by the body.

Cream, spray or powder – and how often? Sprays and powders cloud the air with tiny particles of sunscreen that may not be safe to breathe. Choose creams instead. Reapply them often, because sunscreen chemicals break apart in the sun, wash off and rub off on towels and clothing.

Message for men: Wear sunscreen. Surveys show that 34 percent of men wear sunscreens, compared to 78 percent of women. Start using it now to reduce your cumulative lifetime exposure to damaging UV radiation.

Got your Vitamin D? Many people don’t get enough vitamin D, which skin manufactures in the presence of sunlight. Your doctor can test your level and recommend supplements or a few minutes of sun daily on your bare skin (without sunscreen) if you have low risk for skin cancer. Get tested here

4. Sun Safety Tips For Kids

Kids are more vulnerable to sun damage. A few blistering sunburns in childhood can double a person’s lifetime chances of developing serious forms of skin cancer. The best sunscreen is a hat and shirt. After that, protect kids with a sunscreen that’s effective and safe. Take these special precautions with infants and children:


Infants under six months should be kept out of direct sun as much as possible. Their skin is not yet protected by melanin. So when you take your baby outside:

  • Cover up – Put on protective clothing, tightly woven but loose-fitting, and a sun hat.
  • Make shade – Use the stroller’s canopy or hood. If you can’t sit in a shady spot, put up an umbrella.
  • Avoid midday sun – Take walks in the early morning or late afternoon.
  • Follow product warnings for sunscreen on infants under 6 months old – Most manufacturers advise against using sunscreens on infants or urge parents and caregivers to consult a doctor first. The American Academy of Pediatrics says that small amounts of sunscreen can be used on infants as a last resort when shade can’t be found.

Toddlers and Children

Sunscreens play an essential part of any day in the sun. However, young children’s skin is especially sensitive to chemical allergens as well as the sun’s UV rays. When choosing a sunscreen, keep these tips in mind:

  • Test the sunscreen by applying a small amount on the inside of your child’s wrist the day before you plan to use it. If an irritation or rash develops, try another product. Ask your child’s doctor to suggest a product less likely to irritate a child’s skin.
  • Slop on sunscreen and reapply it often, especially if your child is playing in the water or sweating a lot.
  • Choose your own sunscreen for daycare and school. Some childcare facilities provide sunscreen for the kids, but you can bring your own if you prefer a safer, more effective brand. Share EWG’s safe sunscreen tips and product suggestions with your child’s caregiver.

Sun Safety at School

Sometimes school and daycare policies interfere with children’s sun safety. Many schools treat sunscreen as a medicine and require the child to have written permission to use it. Some insist that the school nurse apply it. Other schools ban hats and sunglasses. Here are a few questions to ask your school:

  • What is the policy on sun safety?
  • Is there shade on the playground?
  • Are outdoor activities scheduled to avoid midday sun?


Teenagers coveting bronzed skin are likely to sunbathe, patronize tanning salons or buy self-tanning products – not good ideas. Researchers believe increasing UV exposure may have caused the marked increase in melanoma incidence among women born after 1965. Tanning parlors expose the skin to as much as 15 times the UV radiation of the sun and likely contribute to the melanoma increase. Many chemicals in self-tanning products have not been tested for safety; the major self-tanning chemical, dihydroxyacetone, is not approved by the FDA for use in cosmetics around the eyes.

Tan does not mean healthy. Here are a few more tips:

  • Make sunscreen a habit for every outdoor sport and activity.
  • Find sun-protective clothing, hats, and sunglasses that you like to wear.
  • To parents of teens: Be good role models – let your teen see you protecting yourself from the sun.

Also, if you know you are going to be exposed to the sun for an extended period of time, we recommend you take extra antioxidants and essential fatty acids to protect against free radical damage.  Here are a couple recommendations:

Be safe and have fun in the sun. Let us know what you think and contact us if you have any questions.

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Blood Flow – Part 2

Last time we discussed the importance of proper blood flow. A lot of people think that cholesterol is a bad guy that clogs up the arteries and causes heart attacks—not true—the problem is when the cholesterol becomes oxidized. Oxidized cholesterol is an inflammatory substance that has been linked to heart attacks. Here is what the authors of a recent study say, “… Our data show that Ox-LDL [oxidized-LDL cholesterol] and hs-CRP levels correlate positively in ACS patients, supporting the hypothesis that Ox-LDL and CRP may play a direct role in promoting the inflammatory component of atherosclerosis in these individuals. We suggest that Ox-LDL/CRP elevated levels may serve as markers of the severity of the disease in evaluation and management of ACS patients.” The problem with elevated cholesterol is that the more cholesterol there is floating around in the blood stream, the greater the potential for oxidation.

Pure Prescriptions

Pure Prescriptions 

Cholesterol is good for you

Cholesterol is a precursor to the major steroid hormones in the body: cortisol, DHEA, testosterone and estrogen. During times of stress there is a greater demand on the body (the liver) to produce these steroid hormones. Both the release of cholesterol from tissue stores and increased cholesterol synthesis may occur as a response to chronic stress.1 If the stress does not subside, and an individual is eating a S.A.D. diet (consisting mostly of high amounts of animal protein and saturated animal fat, high amounts of refined, processed carbohydrates, and low levels of fiber) cholesterol can reach very unhealthy levels. In this situation cholesterol lowering drugs are not getting to the underlying cause of the problem. They are merely managing or suppressing the symptoms.

Elevated cholesterol is not an end-stage pathology that needs to be suppressed. In reality it is often a symptom of a metabolic imbalance. That is why the diet and lifestyle recommendations listed below are so important. In addition, cholesterol damages the cardiovascular system only when it has been altered by oxidation. Cholesterol-lowering medications, such as statin drugs, are often prescribed to individuals with metabolic imbalances associated with the stress response. Unfortunately, one of the adverse effects of these drugs is interruption of the biosynthesis of coenzyme Q10. Therefore, these medications that symptomatically manage elevated cholesterol levels (thereby theoretically decreasing the risk of cardiovascular disease) actually inhibit the body’s production of one of the most important biochemical’s for energy production in the heart – coenzyme Q10.

Why is cholesterol so hyped?

The reason why we are so concerned about cholesterol is because the pharmaceutical industry has done an effective job of convincing its doctors and the general public to “know your cholesterol number.” However, consider the fact that more than half of people dying from a heart attack or stroke have low to normal cholesterol levels. People need to be aware that six of the nine expert members of the government panel that drafted the new lipid panel guidelines (lowering LDL cholesterol level) have either received grants or fees from the companies that make some of the most popular statin drugs, including Pfizer (Lipitor®), Bristol-Myers Squibb (Pravachol®), Merck (Mevacor®), and AstraZeneca (Crestor®). Since the new lowered guidelines will dramatically increase the number of people on statins, perhaps there was a conflict of interest.

Statin drugs are very expensive medicines and carry with them considerable risks for side effects. Some of the side effects noted with statins include:2-3

  • Liver problems and elevated liver function tests.
  • Interference with the manufacture of coenzyme Q10.
  • Rhabdomyolysis (muscle pain and weakness), the breaking down of muscle tissue which can prove fatal.

Perhaps the most natural and least invasive way to impact cholesterol levels is by adding fiber to the diet through food choices and supplements. A review article in the Journal of the American Dietetic Association concluded that soluble fiber supplementation was very effective in lowering cholesterol levels.4 If you currently have a low fiber diet, start out slowly with a dosage of between 1 to 2 grams before meals and at bedtime and gradually increase to 5 grams. Of course it is best to get fiber from a variety of food sources, such as whole grains, vegetables, fruits, and legumes (beans and lentils).

How to prevent oxidation

As we discussed at the top, the problem is not with the level of cholesterol, it’s whether or not the cholesterol is oxidized.  So, how do we keep our cholesterol from becoming oxidized—ANTI-oxidants! That is one reason why the consumption of high-antioxidant fruits, berries, and vegetables is so well-known to prevent heart disease. If your diet is deficient in antioxidants consider supplementing with very high antioxidant superfoods found in NewGreens and NewGreens Berry.

Key References:
  1. Zhang YC, Wei JJ, Wang F, Chen MT, Zhang MZ.Elevated levels of oxidized low-density lipoprotein correlate positively with C-reactive protein in patients with acute coronary syndrome. Cell Biochem Biophys. 2012 Mar;62(2):365-72.
  2. Bland J. Nutritional Endocrinology. 2002.
  3. Murray M. Encyclopedia of Nutritional Supplements. Prima Publishing, 1996.
  4. Murray M. Natural Living. June 21, 2006.
  5. Glore SR, Van Treeck D, Knehans AW, Guild M. Soluble fiber and serum lipids: a literature review. J Am Dietet Assoc 1994;94:425–36.


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Blood Flow

There is probably nothing more important for the human body than proper blood flow. The circulation of blood is how all of our organs receive oxygen and nutrients and many other vital biochemicals. Blood flow is also how we get rid of stuff and allows the liver and kidneys to filter it out so bad things don’t keep re-circulating. Most people do not know what they can do to improve their circulation. There is one product that is unique to any other product on the market and the one that I get the most calls of interest about – Cardiokinase™. Cardiokinase™ offers enhanced support for healthy cardiovascular and cerebrovascular circulation.

What is Cardiokinase?

Cardiokinase™ an improvement on an old ingredient. Cardiokinase is the most advanced, and truly the only legitimate form of nattokinase anywhere.  In 1980, Dr. Hiroyuki Sumi discovered that “natto,” a traditional fermented soybean and medicinal food in Japan, possesses previously unidentified thrombolytic activity.  He referred to the isolated enzyme as nattokinase1.  Although nattokinase is not new to the marketplace, there is a new strain that exhibits some exceptional improvements over the original.  It should be appropriate then that Dr. Sumi himself set the new bar with the scientific development on this new substance.  We will highlight some of the key advancements that clearly differentiate it from any other nattokinase on the market.

How Does Cardiokinase Compare to NSK-SD®?

Before Dr. Sumi exclusively developed Cardiokinase, NSK-SD® was the best brand of nattokinase in the marketplace.  NSK-SD® is very effective at improving circulation with its fibrinolytic activity.  This is where the similarities with Cardiokinase™ end.  This product is the result of the accumulation of Dr. Sumi’s thirty years of scientific research.  Cardiokinase™ features:

  • Over 20% greater fibrinolytic activity than NSK-SD®, exceeding all current standards2
  • Over 10% greater lymphatic absorption than NSK-SD®2
  • Only natural substance demonstrated to lower whole blood viscosity*3
  • Derived from powerful Naruse (“N”) strain and standardized for potency2,4
  • Derived from organically grown Non-GMO soybeans in the U.S.
  • Only nattokinase brand to use corn-free maltodextrin

Why is Fibrinolytic Activity Important?

Fibrin is a protein that naturally forms in the blood after trauma or injury.  The body can also produce fibrin when there is no trauma or injury.  When this type of unhealthy formation occurs, there are major implications for cardiovascular and cerebrovascular health.  The fibrinolytic activity of Cardiokinase can help to:

  • Minimize the formation of an inadvertent blood clot*2
  • Decrease blood sluggishness (anti-viscogenic)*3
  • Improve circulation (release of tissue-plasminogen activator—t-PA)*5-9
  • Maintain healthy effects on blood pressure*8
  • Establish blood cells that are less likely to stick to vessel walls, especially veins, decreasing the development of unhealthy clots*9-10

Many common health concerns, from mild (sore, aching muscles), immune dysfunction, to more serious cardiovascular and cerebrovascular health challenges are caused or worsened by increased blood viscosity and unhealthy clot formation7,11-12.

Is Cardiokinase Safe?

Cardiokinase Nattokinase is a GRAS (Generally Recognized As Safe) affirmed ingredient and is the latest advancement from Dr. Sumi and is shown to be the most powerful and reliable nattokinase available on the market today!

  1. Sumi  H, Thrombolytic enzyme: Characteristics of nattokinase and its application to fibrinolytic treatment through oral administration, Research and development of biologically active substances derived from functional food materials and foodstuffs, Japan Technology Transfer Association,  88–96, 1984.
  1. Sumi H, Functionality of “orally administered capsules and tablets” and foods: New potency assay method for nattokinase. Kurashiki University of Science and the Arts, Department of Life Science.
  1. Pais E, Alexy T, Holsworth RE Jr, Meiselman HJ. Effects of nattokinase, a pro-fibrinolytic enzyme, on red blood cell aggregation and whole blood viscosity. Clin Hemorheol Microcirc. 2006;35(1-2):139-42.
  1. Sumi H, Yatagai C, Naito S, Ohsugi T, Saito J, Substrate Specificity of Nattokinase: Application to the Assay of its Potency. Kurashiki University of Science and the Arts, Department of Life Science. Health & Wellness Section, Honda Trading Corporation, Tokyo, Japan.
  1. Sumi H, Kawahara T, Yatagai C. Heated Natto and Nattokinase Found to have Significant Activity on Human Cells to Promote Release of t-PA. Kurashiki University of Science and the Arts, Department of Life Science.
  1. Yatagai C, Maruyama M, Kawahara, Sumi H. Nattokinase-Promoted Tissue Plasminogen Activator Release from Human Cells. Pathophysiol Haemost Thromb 2007-08;36:227-232.
  1. Hamsten A, de Faire U, Walldius G, et al. Plasminogen activator inhibitor in plasma: risk factor for recurrent myocardial infarction. Lancet 1987;2:3-9.
  1. Kim JY, Gum SN, Paik JK, et al. Effects of nattokinase on blood pressure: a randomized, controlled trial. Hypertens Res. 2008 Aug;31(8):1583-8.
  1. Hsia CH, Shen MC, Lin JS, et al. Nattokinase decreases plasma levels of fibrinogen, factor VII, and factor VIII in human subjects. Nutr Res. 2009 Mar;29(3):190-6.
  1. Feng Y, Junpeng Y, Weiting S, et al. Thrombolytic effect of Subtilisin QK on carrageenan induced thrombosis model in mice. J Thromb Thrombolysis, 18 April 2009.
  1. Brogren H, Karlsson L, Andersson M, Wang L, Erlinge D, Jern S. Platelets synthesize large amounts of active plasminogen activator inhibitor 1. Blood 2004; 104: 3942-8.
  1. Thompson SG, Kienast J, Pyke SDM, Haverkate F, van de Loo JCW.  Hemostatic factors and the risk of myocardial infarction or sudden death in patients with angina pectoris. N Engl J Med 1995;332:635-41.
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Female Hormones 101

There are three main pathways by which the body metabolizes estrogen. These families are the 2-H estrogens, the 4-H estrogens, and the 16-H estrogens. The 4-H and 16-H estrogens are believed to the more carcinogenic. The 2-H estroge’s are believed to be ANTIcarcinogenic. Recently in the Journal of the American Medical Association, it was reported that estrogen replacement therapy (ERT) increases the exposure of the highly estrogenic 4- and 16- hydroxylated estrogens. Also, ERT increases breast density, making early detection by mammography difficult.

How to Promote Healthy Estrogen

Isoflavones (often referred to as phytoestrogens) from soybeans are considered adaptogens for managing estrogen balance. In other words, they help increase estrogen in individuals with a low-estrogen imbalance and they decrease estrogen in those with a high-estrogen imbalance. The soy isoflavones genistein and daidzein are the most studied estrogen-modulating compounds from plants.2-4 Isoflavones from red clover and the Kudzu vine have also been shown to have estrogen activity-modulating effects. In addition to soy, red clover, and the Kudzu vine; chasteberry (Vitex agnus-castus L.), black cohosh (cimicifuga racemosa), and essential fatty acids (such as flax and fish oil), have been demonstrated historically to have hormone activity-modulating affects.

Another way to promote the “friendly” 2-H pathway by lowering the more carcinogenic 16-H pathway is administration of the phytonutrient indole-3-carbinol (I3C).7-8 Now found in capsule form this nutrient is derived from the cruciferous family of vegetables, mostly notably broccoli and to a lessor degree Brussels’ sprouts, cauliflower, and cabbage. Another important and common finding that warrants consideration for perimenopause is low levels of progesterone. This is especially important because, among other reactions in the body, low progesterone is related to a short luteal phase (the part of the menstrual cycle where ovulation occurs) and a short luteal phase is associated with increased bone loss.

Hormones and Bone Density

This is a very important situation to consider because bone mineral density studies are usually not ordered until after menopause but the average age of perimenopause is 47 and bone mineral loss begins at around the age of 40—10 or 15 years before it is usually even tested for. And as with many situations in the body, the earlier an imbalance is detected the better the prognosis. As I indicated in a previous article osteoporosis is the number one bone condition in the United States. Eight million women have osteoporosis, over a million with fractures, many of which were potentially preventable. There are over 70,000 deaths related to preventable hip fractures and over 50,000 requiring long term care.9

Control your Sugar

Another important aspect to recognize is that hyperinsulinemia (high levels of insulin in the blood) influences estrogen synthesis and overall hormone balance or imbalance. A number of nutritional, diet, and lifestyle interventions can improve insulin sensitivity and reduce symptoms associated with these hormone imbalances in women. The dietary program needs to include low glycemic index foods, such as most fruits, berries, nuts, a variety of vegetables, whole grains (not refined grains), fish, eggs, soy products, lean turkey, and lamb.

Know your Thyroid and Vitamin D Levels

Thyroid function is another important area that appears to change in the perimenopausal period. Many of the common symptoms of perimenopause may be attributed to thyroid dysfunction such as weight gain, depression, anxiety, fatigue, cold intolerance, loss of libido, and abnormal menses. As part of the perimenopausal evaluation, I would, therefore, recommend a comprehensive thyroid panel. If hypothroidism is evident, I may suggest the following: elimination of dietary sources of gluten-containing grains such as wheat, and casein-containing products from dairy, such as milk, cheese, etc. These potential food antigens could induce antibodies that cross-react with the thyroid gland. The thyroid gland is very dependent upon sufficient levels of vitamin D. Vitamin D is a powerful hormone- and immune-modulator. Vitamin D is also essential for proper bone density, among many other benefits for the body. In short, get your vitamin D tested. Other nutritional supplements may be beneficial for a thyroid imbalance, give us a call and we can help you with that.

Stress and Adrenal Cortisol

One major underlying issue to consider is that a stress hormone called cortisol plays a major factor in disrupting the orchestrated symphony of the body that is the endocrine hormonal system. Among other lifestyle factors exercise has been proven time and again to have direct positive benefits on stress and on the hormone imbalances related to menopause. Recent studies indicate that moderate physical exercise in menstruating women increases 2-hydroxyestrogen formation.

In another study, the frequency of moderate and severe hot flashes was investigated in postmenopausal women who took part in physical exercise on a regular basis and was compared to that in a control group. The study clearly demonstrated that regular physical exercise (average of 3.5 hours per week) decreased the frequency and severity of hot flashes.

Some other benefits include decreased blood cholesterol levels, decreased bone loss, decreased fat storage, improved ability to deal with stress, improved circulation, improved heart function, increased endurance and energy, increased self-esteem and mood, reduced blood pressure, and relief from hot flashes.

In summary, treatment for symptoms associated with perimenopause needs to be centered around balancing estrogen, raising progesterone levels, controlling insulin and blood sugar, and correcting thyroid imbalances.

In addition to previously mentioned nutrients, I would consider standardized botanical medicines. Black cohosh (Cimicifuga racemosa) helps to reduce hot flashes. Chasteberry (Vitex agnus-castus) used for symptoms of perimenopause. Dong Quai (Angelica sinensis) and licorice (Glycyrrhiza glabra) have also been shown to decrease symptoms associated with perimenopause and menopause. Also consider gamma oryzanol for hot flashes and soy protein isoflavones. Certain individuals may benefit from natural micronized progesterone augmentation. To really understand what your body needs, the best thing you could do is take the guess work out and get tested.

Laboratory Recommendations:

Female hormone Panel (FHP™)

Details: The Female Hormone Panel™ (FHP™) is a non-invasive test consisting of 11 saliva specimens collected during specified time periods throughout the menstrual cycle. The ovaries are a major component of the female reproductive cycle and they release hormones in a cyclical manner which is referred to as the menstrual cycle. The Female Hormone Panel™ provides a dynamic mapping of the free fraction levels of Estradiol (E2) and Progesterone (P) throughout one cycle. In addition, the cycle average of Testosterone (T) and DHEA are measured.

Includes: Estradiol (x11), Progesterone (x11), cycle average Testosterone and DHEA/DHEA-S, 3 Progesterone production indices, 4 Estradiol production indices, a full cycle P/E ratio graph and an example of a restorative plan. The expanded Female Hormone Panel™ (eFHP™) includes an additional five (5) FSH and five (5) LH measurements.

Post Menopause Panel (PostM™)

Details: Menopause is a natural and usually gradual change in glandular function in women resulting in substantial shifts in hormone levels. The Postmenopause Panel™ provides measurements of six key hormones.

Includes: measurements of six key hormones: Estrone (E1), Estradiol (E2), Estriol (E3), Progesterone (P), Testosterone (T) and DHEA, DHEA-S (pooled).

8-Hormone Panel (8-HP™)

Details: Similar to the Adrenal Stress Index, the 8HP includes Cortisol (X4) and DHEA, but it also includes the reproductive hormones: Estradiol, Progesterone, and Testosterone.

Includes: Cortisol (x4), DHEA/DHEA-S, Estradiol, Progesterone, Testosterone

You also may want to consider a basic blood panel that includes Glucose and a Thyroid Panel. Check out Pure Chem Basic™.

The dietary supplements below may be very helpful:

Dietary Recommendations:

  • Eat soy products in moderation (tofu, tempeh, edamame, etc.)
  • Eat more organic vegetables, eggs, onions, nuts and seeds, cruciferous vegetables (broccoli, cauliflower, cabbage, and Brussels’ sprouts), and buckwheat.
  • Eliminate all forms of coffee and start drinking green tea.
  • Replace refined flour products with sprouted grain breads.
  • Eat more legumes and fish, skin-less chicken, and lamb over beef. Only eat organic and hormone-free.
  • Eat more meals at home.

Lifestyle Recommendations:

  • Spend quality time in prayer or meditation every day, connecting with your inner spirit.
  • Take a yoga class twice a week.
  • Have a massage once a month.
  • Take up some form of art that allows for creative expression.
  • Practice breathing exercises.
  • Get in the sun for about 20 minutes each day.
  • If you say you do not have time for these recommendations, sacrifice something else, don’t sacrifice your health. We live in bodies where all the systems are very interrelated in a web-like balance of interactions. We cannot just listen to one instrument when addressing the human body but rather have to respect and consider the entire symphony. As usual, I would recommend a consultation for an individualized, comprehensive assessment.

As usual, if you have any questions about the information in the article, please give us a call.

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2. Ann Med. 29 1997: 95-120.
3. J Natl Cancer Ins.t 83 (1991): 541-6.
4. Gyne. 3 1982: 14-6.
5. Oncogene. 2000; 19: 5764-5771.
6. J Natl Cancer Inst. 1997; 89 (10): 718-723.]
7. Rev Endocr Metab Disord. 2001; 2 (1): 45-64.
8. Comp Therapy. 1992; 18(12): 14-17.
9. Chic Med. 67 1964: 193-5.
10. J Appl Physio. 1997; 83(5): 1551-1556.
11. Acta Obstet Gynecol Scand. 69 (1990): 409-12.
12. N Engl J Med. 1995; 332(24): 1589-93.
13. JAMA. 2001;285(11):1489-1499.


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